A Dolt SQL server can be configured at server start time, or by setting system variables in the SQL session. The simplest way to configure server behavior is to provide a config file with the --config flag. Here's an example file:
log_level: info
read_only: false
autocommit: true
name: root
password: ""
host: localhost
port: 3306
max_connections: 100
read_timeout_millis: 28800000
write_timeout_millis: 28800000
query_parallelism: null
The full list of supported fields can be found in the docs for the sql-server command.

System variables

Dolt defines system variables that you can set in your session via the SET syntax. Many of these can be persisted, so they remain set after a server restart.
set @@dolt_transaction_commit = 1;
A full list of available system variables can be found in the docs on system variables.